IL11 Mouse Models

Why Model IL11

Il11 is the mouse ortholog of human IL11 and encodes interleukin-11, an IL-6-family cytokine that signals through a receptor complex containing gp130. IL-11 has been associated with effects on hematopoiesis and on stromal and epithelial cells.

IL-11 has been associated with fibrosis in several organs, and anti-IL-11 approaches are under study; a recombinant IL-11 has been used to raise platelet counts. Mice with altered IL-11 signaling show developmental and skeletal phenotypes.

Model Applications

Humanized IL11 models, often paired with the IL-11 receptor, have been used to evaluate IL-11-pathway-directed agents in defined experimental settings.

Custom IL11 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Interleukin-11: a central integrative hub driving pathological progression from pulmonary inflammation and fibrosis to cancer. Pharmacol Res. 2025. doi:10.1016/j.phrs.2025.107966
• Paul SR et al. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci U S A. 1990. doi:10.1073/pnas.87.19.7512

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Il11ra1 · Il6st · Il6 · Lif