IL1RL1 Mouse Models

Why Model IL1RL1

Il1rl1 is the mouse ortholog of human IL1RL1 and encodes ST2, a member of the IL-1 receptor family that serves as the receptor for interleukin-33. ST2 exists in membrane-bound and soluble forms and has been associated with type 2 immune responses.

The IL-33/ST2 axis is implicated in asthma and other type 2 inflammatory conditions, and ST2- and IL-33-directed antibodies are under study. Il1rl1-deficient mice show altered type 2 responses.

Model Applications

Humanized IL1RL1 (ST2) models, in which the human protein replaces the mouse counterpart, have been used to evaluate ST2- and IL-33-pathway-directed agents in defined experimental settings.

Custom IL1RL1 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• ST2-mediated neutrophilic airway inflammation: a therapeutic target for patients with uncontrolled asthma. Allergy Asthma Immunol Res. 2024. doi:10.4168/aair.2024.16.1.22
• Yanagisawa K et al. Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1. FEBS Lett. 1993. doi:10.1016/0014-5793(93)81333-u

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Il33 · Il1rap · Il1r1 · Il18r1