Il33 Mouse Models

Why Model Il33

Il33 is the mouse ortholog of human IL33 and encodes interleukin-33, an IL-1-family cytokine that can be released from epithelial and endothelial cells and acts as an alarmin. IL-33 signals through the receptor ST2 and has been associated with promotion of type 2 immune responses.

IL-33 is implicated in asthma and other inflammatory conditions, and IL-33- and ST2-directed antibodies are under clinical study. Il33-deficient mice are viable and show altered type 2 responses in disease models.

Model Applications

Humanized IL33 models, in which the human cytokine replaces the mouse counterpart, have been used to evaluate IL-33-targeted antibodies in defined experimental settings.

Il33 knockout mice have been used to study alarmin biology and type 2 immunity.

Custom Il33 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• The immunomodulatory of interleukin-33 in rheumatoid arthritis: a systematic review. Clin Immunol. 2024. doi:10.1016/j.clim.2024.110264
• Schmitz J et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005. doi:10.1016/j.immuni.2005.09.015

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Il1rl1 · Il1b · Tslp · Il25