ITGB7 Mouse Models

Why Model ITGB7

Itgb7 is the mouse ortholog of human ITGB7 and encodes the integrin β7 subunit, which pairs with α4 to form α4β7 and with αE to form αEβ7. The α4β7 integrin binds MAdCAM-1 and has been associated with homing of lymphocytes to gut-associated tissues.

The α4β7 integrin is the target of the antibody vedolizumab used in inflammatory bowel disease. Itgb7-deficient mice are viable with reduced gut-associated lymphoid tissue.

Model Applications

Humanized ITGB7 models, in which the human subunit replaces the mouse counterpart, have been used to evaluate α4β7-directed agents in defined experimental settings.

Custom ITGB7 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Effectiveness and treatment persistence of vedolizumab compared to anti-tumour necrosis factor-α in patients with Crohn’s disease: a systematic literature review and meta-analysis. United European Gastroenterol J. 2024. doi:10.1002/ueg2.12705
• Erle DJ et al. Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. J Biol Chem. 1991. doi:10.1016/s0021-9258(18)99120-9

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Itga4 · Itgae · Madcam1 · Vcam1