MADCAM1 Mouse Models

Why Model MADCAM1

Madcam1 is the mouse ortholog of human MADCAM1 and encodes mucosal addressin cell adhesion molecule-1 (MAdCAM-1), an immunoglobulin-superfamily adhesion molecule expressed on endothelium in the gut and associated lymphoid tissue. MAdCAM-1 binds the α4β7 integrin and has been associated with lymphocyte homing to the intestine.

The MAdCAM-1/α4β7 axis is a target in inflammatory bowel disease, and MAdCAM-1-directed agents have been evaluated. Madcam1-deficient mice show altered gut lymphocyte homing.

Model Applications

Humanized MADCAM1 models, in which the human protein replaces the mouse counterpart, have been used to evaluate MAdCAM-1-directed agents in defined experimental settings.

Custom MADCAM1 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Selective targeting of α4β7/MAdCAM-1 axis suppresses fibrosis progression by reducing proinflammatory T cell recruitment to the liver. Cells. 2024. doi:10.3390/cells13090756
• Briskin MJ et al. MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. Nature. 1993. doi:10.1038/363461a0

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Itgb7 · Itga4 · Glycam1 · Sell