Ldlr Mouse Models

Why Model Ldlr

Ldlr is the mouse ortholog of human LDLR and encodes the low-density lipoprotein (LDL) receptor, a cell-surface receptor that mediates uptake of LDL particles and has been associated with regulation of plasma cholesterol.

Loss-of-function LDLR mutations cause familial hypercholesterolemia, and the LDL-receptor pathway is central to lipid-lowering therapy; agents such as statins and PCSK9 inhibitors act in part by increasing LDL-receptor activity. Ldlr-deficient mice develop elevated cholesterol and atherosclerosis on appropriate diets and are widely used in cardiovascular research.

Model Applications

Ldlr knockout mice are widely used to study atherosclerosis and lipid metabolism. Humanized LDLR models, in which the human receptor replaces the mouse counterpart, have been used to study LDL-receptor regulation and lipid-lowering agents in defined experimental settings.

Custom Ldlr Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• A comparative analysis of low-density lipoprotein cholesterol (LDL-C)-lowering activities of bempedoic acid, inclisiran, and PCSK9 inhibitors: a systematic review. Cureus. 2024. doi:10.7759/cureus.69900
• Sudhof TC et al. The LDL receptor gene: a mosaic of exons shared with different proteins. Science. 1985. doi:10.1126/science.2988123

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Pcsk9 · Apob · Ldlrap1 · Apoe