Conventional / global / constitutive KO
●6 Models Available
Ldlr Conditional Knockout, Knockin, Knockout mouse models
Browse 6 Ldlr mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Ldlr conditional knockout mouse, Ldlr knockin mouse, Ldlr knockout mouse, Ldlr xenograft-applicable mouse. Request a quote within 24 hours.
Why model Ldlr
Ldlr, the mouse ortholog of human LDLR, encodes the cell surface receptor that clears apoB-containing lipoproteins, built from seven class A cysteine-rich ligand-binding repeats, EGF-A and EGF-B modules flanking a beta-propeller that mediates acid-dependent ligand release, an O-linked sugar domain, and a cytoplasmic NPXY motif read by Ldlrap1 for clathrin-mediated internalization; Pcsk9 binding to EGF-A diverts the receptor to lysosomal degradation instead of recycling, and Mylip ubiquitination provides a sterol-responsive degradation route. Loss-of-function alleles cause familial hypercholesterolemia, and null mice are viable but develop hypercholesterolemia and atherosclerosis on Western diet, making them a standard cardiovascular platform. Allele choice follows the question: a null for plaque biology, patient point mutations for class-specific trafficking defects, and full humanization when the endpoint is PCSK9 antibody efficacy, siRNA silencing, or base editing of the human sequence. Combining with Apoe or Apobec1 alleles tunes lipoprotein profiles toward human-like distributions.
What Ldlr mouse models are available?
ingenious targeting laboratory offers 6 distinct Ldlr (LDLR) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 6 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Ldlr model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ldlr allele types
Knockout, conditional, knockin, humanized, and related paths for Ldlr (human LDLR). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ldlr catalog models
6 Ldlr lines with QC documentation and technical support. Ldlr floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Ldlr-Flox
Conditional KnockoutKO/CKO mice
liveCKO 210188 - Order
Ldlr-C223R
Knockinpoint mutantion mice
embryo cryopreservationKI 00043 - Order
Ldlr-KO
KnockoutKO/CKO mice
embryo cryopreservationKO 190559 - Order
Ldlr-KO(2)
KnockoutKO/CKO mice, disease model mice
liveKO 210198 - Order
Ldlr-KO/Apoe-KO
Xenograft-ApplicableKO/CKO mice
liveXA 252291 - Order
Ldlr-KO/Ifngr1-KO
Xenograft-ApplicableKO/CKO mice
liveXA 250834
Looking for a Ldlr mouse model?
We have 6 Ldlr models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model6
Models Available
4
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ldlr Mouse Model Types
A Ldlr knockout mouse has the Ldlr gene permanently inactivated, enabling loss of function studies. A Ldlr conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ldlr, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Ldlr knockin models carry a precisely inserted sequence at the Ldlr locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Ldlr organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Ldlr.