MMP9 Mouse Models

Why Model MMP9

Mmp9 is the mouse ortholog of human MMP9 and encodes matrix metalloproteinase-9 (gelatinase B), a secreted enzyme that degrades components of the extracellular matrix, including type IV collagen. MMP-9 has been associated with tissue remodeling, inflammation, and cell migration.

MMP-9 has been associated with cancer invasion, fibrosis, and inflammatory conditions, and MMP-9-directed approaches have been studied. Mmp9-deficient mice show altered tissue remodeling and inflammatory responses.

Model Applications

Humanized MMP9 models, in which the human protein replaces the mouse counterpart, have been used to evaluate MMP-9-directed agents in defined experimental settings.

Custom MMP9 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• The role of matrix metalloproteinase 9 in fibrosis diseases and its molecular mechanisms. Biomed Pharmacother. 2024. doi:10.1016/j.biopha.2023.116116
• Wilhelm SM et al. SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. J Biol Chem. 1989. doi:10.1016/s0021-9258(18)71480-4

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Mmp2 · Timp1 · Timp2 · Mmp14