TNFRSF4 Mouse Models

Why Model TNFRSF4

Tnfrsf4 is the mouse ortholog of human TNFRSF4 and encodes OX40 (CD134), a costimulatory TNF-receptor-superfamily member expressed mainly on activated T cells. Engagement of OX40 by OX40 ligand has been associated with enhanced T-cell proliferation, survival, and cytokine production.

OX40 is a target of agonist antibodies in cancer immunotherapy and of antagonist approaches in inflammatory diseases such as atopic dermatitis. Tnfrsf4-deficient mice are viable with altered T-cell responses in some models.

Model Applications

Humanized TNFRSF4 (OX40) models, in which the human receptor replaces the mouse counterpart, have been used to evaluate OX40 agonists and antagonists in immunocompetent mice, sometimes combined with OX40L humanization.

Custom TNFRSF4 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• OX40/OX40 ligand and its role in precision immune oncology. Cancer Metastasis Rev. 2024. doi:10.1007/s10555-024-10184-9
• Mallett S et al. Characterization of the MRC OX40 antigen of activated CD4-positive T lymphocytes. EMBO J. 1990. doi:10.1002/j.1460-2075.1990.tb08211.x

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Tnfsf4 · Cd28 · Tnfrsf9 · Tnfrsf18