Tnfrsf9 Mouse Models

Why Model Tnfrsf9

Tnfrsf9 is the mouse ortholog of human TNFRSF9 and encodes 4-1BB (CD137), a costimulatory TNF-receptor-superfamily member expressed on activated T cells and other immune cells. Engagement of 4-1BB by its ligand has been associated with enhanced T-cell proliferation and survival.

4-1BB is a target of agonist antibodies and bispecific agents in cancer immunotherapy, and the 4-1BB signaling domain is used in some chimeric antigen receptors. Tnfrsf9-deficient mice are viable with altered T-cell responses in some models.

Model Applications

Humanized TNFRSF9 (4-1BB) models, in which the human receptor replaces the mouse counterpart, have been used to evaluate 4-1BB agonists and bispecific agents in immunocompetent mice.

Custom Tnfrsf9 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• 4-1BB immunotherapy: advances and hurdles. Exp Mol Med. 2024. doi:10.1038/s12276-023-01136-4
• Kwon BS, Weissman SM. cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci U S A. 1989. doi:10.1073/pnas.86.6.1963

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Tnfsf9 · Cd28 · Tnfrsf4 · Tnfrsf18