Asl cDNA Knockin Mouse
Since 1998, ingenious targeting laboratory has delivered 2,800+ projects with 100% germline transmission guarantee and 800+ peer reviewed publications.
Asl is a common request for cdna knockin mouse models. ingenious targeting laboratory designs and delivers the line to your study specification with documented milestones.
Get a Quote in 24 HoursWhat Asl cDNA Knockin mouse models are available?
ingenious targeting laboratory designs and generates Asl cdna knockin mouse models to your specification. Quotes return in about 24 hours with documented germline transmission and strict United States QC guidelines.
Scientific design
Asl is a well studied locus in mouse genetics. Allele design follows your phenotype goals and what the published landscape already shows for this gene.
2 existing alleles are indexed for Asl, including 1 conditional, including 1 knockout. Where the published set lacks the modification you need, ingenious targeting laboratory builds that allele with documented germline transmission.
Knockin alleles insert sequence at the endogenous locus under native regulation. Homologous recombination targeting confirms junction integrity and expression pattern before germline transmission, which keeps physiological control cleaner than random integration.
Quotes return in about 24 hours with milestones, pricing, and options for cryo or live dispatch.
What researchers say
“ingenious targeting laboratory delivered exactly the floxed allele we designed, with clear milestones and germline confirmed founders.”
“The team translated our humanization requirements into a knockin strategy we could breed and phenotype on schedule.”
“Clear communication on allele design and germline transmission made our conditional knockout program straightforward to execute.”
Selected publications
- Unexpected survival of mice carrying a mutation in Pygo2 that strongly reduces its binding to Bcl9/9l
- Pax6-dependent, but beta-catenin-independent, function of Bcl9 proteins in mouse lens development.
- The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.
- Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
FAQ
What Asl cDNA Knockin mouse models are available?
When Asl cDNA Knockin lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Asl knockout embryonic lethal in mice?
It depends on background and allele design. Some Asl germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Asl animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Asl?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.