Conventional / global / constitutive KO
●1 Model Available
Brca1 Conditional Knockout mouse model
Browse 1 Brca1 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Brca1
Brca1, mouse ortholog of human BRCA1, encodes a RING domain E3 ubiquitin ligase that heterodimerizes obligately with BARD1 and uses tandem BRCT repeats to read phosphopeptides on ABRAXAS, BACH1 and CTIP, assembling distinct complexes that antagonize 53BP1 and shieldin at break ends, license end resection, and promote RAD51 loading for homologous recombination. Loss produces the BRCAness state of HR deficiency, replication fork instability and PARP inhibitor sensitivity, with tumor spectra concentrated in mammary and ovarian epithelium. Homozygous null mice die during early embryogenesis, rescued partially by Trp53 loss, so conditional exon 11 or full null floxed alleles combined with mammary Cre drivers and a p53 allele constitute the canonical model. Separation-of-function knockins, notably RING-deficient and BRCT phospho-binding mutants, distinguish ligase activity from scaffolding and explain PARP inhibitor resistance through 53BP1 loss. Choose conditional nulls for tumorigenesis and drug response, and precise variant knockins for clinical variant reclassification, always pairing with a validated epithelial Cre.
What Brca1 mouse models are available?
ingenious targeting laboratory offers 1 distinct Brca1 (BRCA1) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Brca1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Brca1 allele types
Knockout, conditional, knockin, humanized, and related paths for Brca1 (human BRCA1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Brca1 catalog models
1 Brca1 line with QC documentation and technical support. Brca1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Brca1-Flox
Conditional KnockoutKO/CKO mice, disease model mice
sperm cryopreservationCKO 18007
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Brca1 (BRCA1) from ITL supported projects.
- Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis.Amleh A, Nair SJ, Sun J, Sutherland A, Hasty P, Li R. (2009). PLoS One4: e5034
Looking for a Brca1 mouse model?
We have 1 Brca1 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Brca1 Mouse Model Types
A Brca1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Brca1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Brca1 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Brca1.