What Trp53 Conditional Knockout mouse models are available?

When Trp53 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Trp53 knockout embryonic lethal in mice?

It depends on background and allele design. Some Trp53 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Trp53 animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Trp53?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●20 Models Available

READY TO SHIP!

LIVE · SPERM · EMBRYO

Trp53 Conditional Knockout, Knockin, Knockout mouse models

Browse 20 Trp53 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Trp53 conditional knockout mouse, Trp53 knockin mouse, Trp53 knockout mouse, Trp53 xenograft-applicable mouse. Request a quote within 24 hours.

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Why model Trp53

Trp53, the mouse ortholog of human TP53, encodes the tetrameric transcription factor whose central DNA-binding core reads p53 response elements at Cdkn1a, Mdm2, Bbc3, Pmaip1, and Zmat3, coupling ATM and ATR phosphorylation of the amino-terminal transactivation domains to arrest, senescence, and mitochondrial apoptosis while MDM2 and MDM4 impose continuous ubiquitin-dependent turnover. Because most human alleles are missense rather than deleted, the design fork is decisive: conditional or germline nulls model pure suppressor loss and yield thymic lymphoma and sarcoma, whereas structural and contact hotspot knockins such as R172H and R270H (human R175H and R273H) confer dominant-negative and gain-of-function metastatic behavior that a null never reproduces. Lox-stop-lox and restorable alleles interrogate reactivation therapeutics, and humanized TP53 supports MDM2 inhibitor and mutant-reactivator pharmacology. Note that Trp63 and Trp73 share response elements and can buffer apoptotic output, so match allele class to tumor spectrum, latency, and drug response endpoints deliberately.

What Trp53 mouse models are available?

ingenious targeting laboratory offers 20 distinct Trp53 (TP53) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
20 Ready Catalog Lines	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Xenograft Applicable Strains

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Xenograft Applicable Strains

Trp53 model types

PathAvailability

Knockout
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Conditional knockout
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Knockin
View catalog
Humanized
Request a quote
Transgenic / overexpression
Request a quote

Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Trp53 allele types

Knockout, conditional, knockin, humanized, and related paths for Trp53 (human TP53). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO

Inducible conditional KO

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI

Tag KI

Conditional KI

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Targeted Transgenic

Safe harbor

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre

Tamoxifen or dox inducible Cre

Dual recombinase

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Gene specific reporter knockin

Standalone reporter catalog

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Available Trp53 catalog models

20 Trp53 lines with QC documentation and technical support. Trp53 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

Trp53-Flox
CKO
CKO, Disease Model
These Trp53 flox mice possess loxP sites flanking exons 5-7 via ESC targeting. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.
LiveCKO 18005
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Trp53-Flox
CKO
CKO, Disease Model
These mice carry rox sites flanking exon 5-7 of Trp53 gene. When crossed with a Dre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Trp53 gene.
Sperm CryopreservedCKO 190067
Order
Trp53-Flox/Kras-LSL-G12D
CKO
CKO, Point Mutation
The Trp53-Flox(CKO 18005) was crossed with Kras-LSL-G12D(KI 190003) to generate Trp53-Flox/Kras-LSL-G12D mice.
LiveCKO 233079
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Trp53-LSL-R172H
KI
Point Mutation, Disease Model
These mice carry a R172H conditional mutation of Trp53 gene.
Sperm CryopreservedKI 220071
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Trp53-R172H
KI
Point Mutation, Disease Model
These mice carry a p.R172H mutation of Trp53 gene.
LiveKI 18028
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Trp53-R270H
KI
Point Mutation, Disease Model
These mice carry a p.R270H mutation of Trp53 gene.
Embryo CryopreservedKI 18027
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Trp53-LSL-R270H
KI
Point Mutation
These mice carry a p.R270H conditional mutation of Trp53 gene.
Sperm CryopreservedKI 200186
Order
Trp53-LSL-R172H/R26-CAG-LSL-HPV-E6-CAG-LSL-HPV-E7-IRES-Luc/Krt14-CreERT2
KI
Overexpression, Cre/Dre Toolbox, Fluorescent Model
The Trp53-LSL-R172H was crossed with R26-CAG-LSL-HPV-E6-CAG-LSL-HPV-E7-IRES-Luc/Krt14-CreERT2（KI 234663）to generate Trp53-LSL-R172H/R26-CAG-LSL-HPV-E6-CAG-LSL-HPV-E7-IRES-Luc/Krt14-CreERT2 mice.
Embryo CryopreservedKI 234952
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Trp53-R245W
KI
Point Mutation
These mice carry a R245W mutation of Trp53 gene.
Sperm CryopreservedKI 225098
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Trp53-R172H/Kras-LSL-G12D(2)
KI
Point Mutation
Trp53-R172H(KI 18028)were crossed with Kras-LSL-G12D(KI 190003)to generate Trp53-R172H/Kras-LSL-G12D(KI 230388) mice.
LiveKI 230388
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Trp53-FSF-R270H
KI
Point Mutation
These mice carry a p.R270H conditional mutation of Trp53 gene.
Sperm CryopreservedKI 210364
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Trp53-KO
KO
KO
A neo cassette replaces exons 2-11,including the start codon,of Trp53 (transformation related protein 53).Null homozygotes show high, early-onset tumor incidence;some have persistent hyaloid vasculature and cataracts.
Embryo CryopreservedKO 00011
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Trp53-KO(2)
KO
KO, Disease Model
Exon 5-7 of Trp53 gene was deleted to generate Trp53 knockout mice.
F0 Embryo CryopreservedKO 191203
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Trp53-KO(5)
KO
KO
The exon 2-11 of Trp53 gene was deleted to generate Trp53 knockout mouse.
LiveKO 250665
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Trp53-KO/Nf1-Flox
KO
CKO
On the basis of Nf1-Flox(CKO 200018) strain, the exon 2-11 of Trp53 gene was deleted to generate Trp53 knockout mouse.
Sperm CryopreservedKO 242359
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Trp53-Flox/R26-CreERT2
XA
CKO, Cre/Dre Toolbox
The Trp53-Flox(CKO 18005) was crossed with R26-CreERT2(KI 200041) to generate Trp53-Flox/R26-CreERT2 mice.
LiveXA 251497
Order
Trp53-Flox/Stk11-Flox/Kras-LSL-G12D
XA
KO, Point Mutation
The Trp53-Flox(CKO 18005) was crossed with Stk11-Flox/Kras-LSL-G12D(XA 250001) to generate Trp53-Flox/Stk11-Flox/Kras-LSL-G12D mice.
LiveXA 250002
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Trp53-Flox/Pten-Flox
XA
CKO
The Trp53-Flox(CKO 18005) was crossed with Pten-Flox(CKO 18004) to generate Trp53-Flox/Pten-Flox mice.
LiveXA 241867
Order
Trp53-Flox/Pten-Flox/Pbsn-2A-CreERT2
XA
CKO, Cre/Dre Toolbox
The Trp53-Flox(CKO 18005) was crossed with Pten-Flox/Pbsn-2A-CreERT2(XA 242163) to generate Trp53-Flox/Pten-Flox/Pbsn-2A-CreERT2 mice.
LiveXA 242164
Order
Trp53-Flox/Kras-LSL-G12D/Mras-KO
XA
KO, Point Mutation
The Trp53-Flox/Kras-LSL-G12D (CKO 233079) was crossed with Mras-KO(KO 241488) to generate Trp53-Flox/Kras-LSL-G12D/Mras-KO mice.
Embryo CryopreservedXA 251978
Order

Selected publications from ingenious targeting laboratory

Peer reviewed work involving Trp53 (TP53) from ingenious supported projects.

Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells.Sellar RS, Sperling AS, Słabicki M, Gasser JA, McConkey ME, Donovan KA, Mageed N, Adams DN, Zou C, Miller PG, Dutta RK, Boettcher S, Lin AE, Sandoval B, Quevedo Barrios VA, Kovalcik V, Koeppel J, Henderson EK, Fink EC, Yang L, Chan A, Pangeni Pokharel S, Bergstrom EJ, Burt R, Udeshi ND, Carr SA, Fischer ES, Chen C-W, Ebert BL. (2022). J Clin Invest 132(16): e153514

View all ingenious publications

Looking for a Trp53 mouse model?

We have 20 Trp53 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation

About Trp53 Mouse Model Types

A Trp53 knockout mouse has the Trp53 gene permanently inactivated, enabling loss of function studies. A Trp53 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Trp53, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Trp53 knockin models carry a precisely inserted sequence at the Trp53 locus, useful for reporter, tag, or humanization studies.

Knockout Mouse Models Conditional Knockout Mouse Models Knockin Mouse Models Mouse Model Generation Services

Modifications available

Jump to catalog backed pages for Trp53 organized by modification type. Each URL is indexable and matches common search patterns.

Trp53 Conditional Knockout Trp53 Knockin Trp53 Knockout Trp53 Xenograft-Applicable Trp53 cDNA Knockin Trp53 Epitope Tag Knockin Trp53 Humanized Trp53 Inducible Knockout Trp53 Overexpression / Safe Harbor Trp53 Reporter

Tissue-specific options

Catalog backed tissue and driver restricted routes for Trp53.

liver Trp53 conditional knockout Albumin-Cre Trp53 conditional knockout

Related Gene Targets

Trp53bp1 Trp53bp2 Trp53inp1 Trp53rkb Trp63 Trp73 Trpa1 Trpc1 Trpc3 Trpc4

Breed this line with ingenious targeting laboratory

Send the Trp53 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Live colonies

Trp53 models ready to ship

Get a confirmed quote in 24 hours. All Trp53 models ship with full QC documentation, health certificates, and lifetime technical support.

Trp53Study ready strains in catalog

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Model generation

Need a knockout, knockin, or humanized line?

Specialized conventional and conditional knockouts
Knockins including point mutations, cDNA insertions, and epitope tags
Humanized models, including partial and full gene replacements
Targeted transgenesis in safe harbor loci
Inducible/reversible alleles using advanced recombinase techniques

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 2,800+ custom models generated since 1998. 100% germline transmission guarantee.

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