What Trp53 Conditional Knockout mouse models are available?

When Trp53 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Trp53 knockout embryonic lethal in mice?

It depends on background and allele design. Some Trp53 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Trp53 animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Trp53?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●21 Models Available

Trp53 Conditional Knockout, Knockin, Knockout mouse models

Browse 21 Trp53 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Trp53 conditional knockout mouse, Trp53 knockin mouse, Trp53 knockout mouse, Trp53 xenograft-applicable mouse. Request a quote within 24 hours.

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Why model Trp53

Trp53, the mouse ortholog of human TP53, encodes the tetrameric transcription factor whose central DNA-binding core reads p53 response elements at Cdkn1a, Mdm2, Bbc3, Pmaip1, and Zmat3, coupling ATM and ATR phosphorylation of the amino-terminal transactivation domains to arrest, senescence, and mitochondrial apoptosis while MDM2 and MDM4 impose continuous ubiquitin-dependent turnover. Because most human alleles are missense rather than deleted, the design fork is decisive: conditional or germline nulls model pure suppressor loss and yield thymic lymphoma and sarcoma, whereas structural and contact hotspot knockins such as R172H and R270H (human R175H and R273H) confer dominant-negative and gain-of-function metastatic behavior that a null never reproduces. Lox-stop-lox and restorable alleles interrogate reactivation therapeutics, and humanized TP53 supports MDM2 inhibitor and mutant-reactivator pharmacology. Note that Trp63 and Trp73 share response elements and can buffer apoptotic output, so match allele class to tumor spectrum, latency, and drug response endpoints deliberately.

What Trp53 mouse models are available?

ingenious targeting laboratory offers 21 distinct Trp53 (TP53) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
21 Ready Catalog Lines	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Xenograft Applicable Strains

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Xenograft Applicable Strains

Trp53 model types

PathAvailability

Knockout
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Conditional knockout
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Knockin
View catalog
Humanized
Request a quote
Transgenic / overexpression
Request a quote

Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Trp53 allele types

Knockout, conditional, knockin, humanized, and related paths for Trp53 (human TP53). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

Browse Full Catalog

Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

Request a Quote Explore model generation services

Available Trp53 catalog models

21 Trp53 lines with QC documentation and technical support. Trp53 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

Trp53-Flox
Conditional Knockout
KO/CKO mice, disease model mice
sperm cryopreservationCKO 190067
Order
Trp53-Flox/Kras-LSL-G12D
Conditional Knockout
KO/CKO mice,point mutantion mice
liveCKO 233079
Order
Trp53-Flox
Conditional Knockout
KO/CKO mice, disease model mice
liveCKO 18005
Order
Trp53-LSL-R172H
Knockin
point mutantion mice, disease model mice
sperm cryopreservationKI 220071
Order
Trp53-R172H
Knockin
point mutantion mice, disease model mice
liveKI 18028
Order
Trp53-R270H
Knockin
point mutantion mice, disease model mice
embryo cryopreservationKI 18027
Order
Trp53-LSL-R270H
Knockin
point mutantion mice
sperm cryopreservationKI 200186
Order
Trp53-FSF-R270H
Knockin
point mutantion mice
sperm cryopreservationKI 210364
Order
Trp53-LSL-R172H/R26-CAG-LSL-HPV-E6-CAG-LSL-HPV-E7-IRES-Luc/Krt14-CreERT2
Knockin
over expression mice,Cre/Dre Toolbox of Mice, fluorescent mouse
embryo cryopreservationKI 234952
Order
Trp53-R245W
Knockin
point mutantion mice
sperm cryopreservationKI 225098
Order
Trp53-R172H/Kras-LSL-G12D(2)
Knockin
point mutantion mice
liveKI 230388
Order
Trp53-KO(2)
Knockout
KO/CKO mice, disease model mice
embryo cryopreservationKO 191203
Order
Trp53-KO(5)
Knockout
KO/CKO mice
liveKO 250665
Order
Trp53-KO
Knockout
KO/CKO mice
liveKO 00011
Order
Trp53-KO/Nf1-Flox
Knockout
KO/CKO mice
sperm cryopreservationKO 242359
Order
Trp53-Flox/Kras-LSL-G12D/Alb-Cre-Tg(NMX)
Xenograft-Applicable
KO/CKO mice,point mutantion mice,Cre/Dre Toolbox of Mice, random transgenic mice
liveXA 251927
Order
Trp53-Flox/Stk11-Flox/Kras-LSL-G12D
Xenograft-Applicable
KO/CKO mice,point mutantion mice
embryo cryopreservationXA 250002
Order
Trp53-Flox/Alb-Cre-Tg(NMX)
Xenograft-Applicable
KO/CKO mice,Cre/Dre Toolbox of Mice, random transgenic mice
liveXA 252654
Order
Trp53-Flox/R26-CreERT2
Xenograft-Applicable
KO/CKO mice,Cre/Dre Toolbox of Mice
liveXA 251497
Order
Trp53-Flox/Pten-Flox/Pbsn-2A-CreERT2
Xenograft-Applicable
KO/CKO mice,Cre/Dre Toolbox of Mice
liveXA 242164
Order
Trp53-Flox/Pten-Flox
Xenograft-Applicable
KO/CKO mice
liveXA 241867
Order

Selected publications from ingenious targeting laboratory

Peer reviewed work involving Trp53 (TP53) from ITL supported projects.

Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells.Sellar RS, Sperling AS, Słabicki M, Gasser JA, McConkey ME, Donovan KA, Mageed N, Adams DN, Zou C, Miller PG, Dutta RK, Boettcher S, Lin AE, Sandoval B, Quevedo Barrios VA, Kovalcik V, Koeppel J, Henderson EK, Fink EC, Yang L, Chan A, Pangeni Pokharel S, Bergstrom EJ, Burt R, Udeshi ND, Carr SA, Fischer ES, Chen C-W, Ebert BL. (2022). J Clin Invest 132(16): e153514

View all ITL publications

Looking for a Trp53 mouse model?

We have 21 Trp53 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

Order catalog model

Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation

About Trp53 Mouse Model Types

A Trp53 knockout mouse has the Trp53 gene permanently inactivated, enabling loss of function studies. A Trp53 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Trp53, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Trp53 knockin models carry a precisely inserted sequence at the Trp53 locus, useful for reporter, tag, or humanization studies.

Knockout Mouse Models Conditional Knockout Mouse Models Knockin Mouse Models Mouse Model Generation Services

Modifications available

Jump to catalog backed pages for Trp53 organized by modification type. Each URL is indexable and matches common search patterns.

Trp53 Conditional Knockout Trp53 Knockin Trp53 Knockout Trp53 Xenograft-Applicable Trp53 cDNA Knockin Trp53 Epitope Tag Knockin Trp53 Humanized Trp53 Inducible Knockout Trp53 Overexpression / Safe Harbor Trp53 Reporter

Tissue-specific options

Catalog backed tissue and driver restricted routes for Trp53.

liver Trp53 conditional knockout Albumin-Cre Trp53 conditional knockout

Related Gene Targets

Trp53bp1 Trp53bp2 Trp53inp1 Trp63 Trp73 Trpa1 Trpc1 Trpc3 Trpc4 Trpc4Ap