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Bcl6 Xenograft-Applicable mouse models
B cell lymphoma 6, encoded by Bcl6 and orthologous to human BCL6, is a BTB/POZ zinc finger transcriptional repressor whose homodimer lateral groove recruits NCOR, SMRT, and BCOR corepressors while its RD2 region engages MTA3 and NuRD. As master regulator of the germinal center reaction it silences Trp53, Cdkn1a, Atr, and Prdm1, permitting tolerated DNA damage during somatic hypermutation and blocking plasma cell differentiation. Lymphoma activation arises from IGH or promoter substitution translocations and 5-prime regulatory mutations that prevent normal downregulation, yielding constitutive expression in diffuse large B cell lymphoma. Design accordingly: conditional deletion defines germinal center dependency, a knockin or promoter substitution allele driving sustained expression models lymphomagenesis, and BTB groove point mutants separate corepressor-dependent from independent functions for degrader and inhibitor programs. Germline nulls are viable but develop inflammatory myocarditis, so Cd19-Cre or Cgamma1-Cre restriction keeps phenotypes interpretable against B cell endpoints.
Orthotopic and subcutaneous routes both benefit from consistent Bcl6 genetics across cages.
What Bcl6 Xenograft-Applicable mouse models are available?
ingenious targeting laboratory offers 2 distinct Bcl6 xenograft-applicable catalog mouse models. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Bcl6-Flox/Lyz2-CreERT2-IRES-EGFP | XA | Other | DEVELOPING | XA 263944 | Inquire |
| The Bcl6-Flox (CKO 242010) was crossed with Lyz2-CreERT2-IRES-EGFP(KI 18047) to generate Bcl6-Flox/Lyz2-CreERT2-IRES-EGFP mice. | |||||
| Bcl6-Flox/Col2a1-2A-CreERT2 | XA | CKO, Cre/Dre Toolbox | DEVELOPING | XA 262000 | Inquire |
| The Bcl6-Flox (CKO 242010) was crossed with Col2a1-2A-CreERT2(KI 18029) to generate Bcl6-Flox/Col2a1-2A-CreERT2 mice. | |||||
Why this approach
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For your target tissue centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
Pricing and quotes
The Bcl6 Xenograft-Applicable lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Bcl6 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Bcl6 Xenograft-Applicable mouse models are available?
When Bcl6 Xenograft-Applicable lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Bcl6 knockout embryonic lethal in mice?
It depends on background and allele design. Some Bcl6 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Bcl6 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Bcl6?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Related models and routes
Breed this line with ITL
Send the Bcl6 Xenograft-Applicable line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.