C1qb Knockout mouse models
Mouse C1qb is the ortholog of human C1QB and encodes the B chain that, in strict one-to-one stoichiometry with the A and C chains, forms the ABC heterotrimeric subunits whose triple-helical collagen regions bundle into the stalk of the hexameric C1q molecule. The B chain gC1q head carries much of the charge pattern used for immune complex recognition, and correct chain assembly in the endoplasmic reticulum is a prerequisite for secretion, which is why disrupting C1qb abolishes circulating C1q entirely rather than reducing it proportionally. Downstream consequences include loss of classical pathway initiation, defective clearance of apoptotic debris, glomerular immune complex accumulation, and reduced complement-dependent synaptic pruning. Because no paralog substitutes, single-gene deletion is fully informative, but for cell-source questions a conditional flox allele combined with microglial (Cx3cr1-CreER) or myeloid Cre is preferable, and full-locus humanization suits classical pathway therapeutics whose epitopes are species restricted.
Global C1qb deletion answers broad mechanism questions quickly. If timing or site matters, conditional alleles are a natural next step after the null is characterized.
What C1qb Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct C1qb knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| C1qb-KO | Knockout | KO/CKO mice | sperm cryopreservation | KO 190758 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The C1qb Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a C1qb allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What C1qb Knockout mouse models are available?
When C1qb Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is C1qb knockout embryonic lethal in mice?
It depends on background and allele design. Some C1qb germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live C1qb animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for C1qb?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.