C2 Reporter Mouse
Since 1998, ingenious targeting laboratory has delivered 2,800+ projects with 100% germline transmission guarantee and 800+ peer reviewed publications.
C2 is a common request for reporter mouse models. ingenious targeting laboratory designs and delivers the line to your study specification with documented milestones.
Get a Quote in 24 HoursWhat C2 Reporter mouse models are available?
ingenious targeting laboratory designs and generates C2 reporter mouse models to your specification. Quotes return in about 24 hours with documented germline transmission and strict United States QC guidelines.
Scientific design
C2 is a well studied locus in mouse genetics. Allele design follows your phenotype goals and what the published landscape already shows for this gene.
1 existing allele are indexed for C2, including 1 knockout. Where the published set lacks the modification you need, ingenious targeting laboratory builds that allele with documented germline transmission.
Reporter alleles fuse a detectable marker to endogenous regulation so expression mirrors the native locus. Pre germline characterization confirms signal location before germline transmission.
Quotes return in about 24 hours with milestones, pricing, and options for cryo or live dispatch.
Reporter options for C2
C2 GFP reporter
Green fluorescent protein fused to C2 regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
C2 YFP reporter
Yellow fluorescent protein fused to C2 regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
C2 RFP reporter
Red fluorescent protein fused to C2 regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
C2 mCherry reporter
Monomeric Cherry fluorescent protein fused to C2 regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
C2 tdTomato reporter
Tandem dimer Tomato fused to C2 regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
C2 lacZ reporter
Beta galactosidase reporter fused to C2 regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
C2 Luciferase reporter
Bioluminescent reporter fused to C2 regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
What researchers say
“ingenious targeting laboratory delivered exactly the floxed allele we designed, with clear milestones and germline confirmed founders.”
“The team translated our humanization requirements into a knockin strategy we could breed and phenotype on schedule.”
“Clear communication on allele design and germline transmission made our conditional knockout program straightforward to execute.”
Selected publications
- Dec2 inhibits macrophage pyroptosis to promote periodontal homeostasis
- Rhythmic expression of DEC2 protein in vitro and in vivo.
- Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration
- Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1alpha and MED1 complex.
FAQ
What C2 Reporter mouse models are available?
When C2 Reporter lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is C2 knockout embryonic lethal in mice?
It depends on background and allele design. Some C2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live C2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for C2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.