Cdk12 Conditional Knockout mouse — Nestin-Cre pairing
Conditional deletion of Cdk12 limits the genetic change to the lineage you choose. That helps in oncology, immunology, and metabolic work where systemic loss would muddy the read. After you confirm Cre specificity, crossing to Cdk12 floxed stock yields usable cohorts. For neural work, plan Cre specificity, reporter crosses, and baseline phenotyping before you scale.
Driver pairing
Nestin-Cre biases toward neural. Inducible: no.
Catalog options
Conditional knockout focuses the experiment on neuron while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
| Model | Type | Category | Availability | Catalog # | |
|---|---|---|---|---|---|
| Cdk12-Flox | Conditional Knockout | KO/CKO mice | embryo cryopreservation | CKO 190059 | Inquire |
Pricing and quotes
The Cdk12 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Cdk12 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with milestones for genotyping, QC, and dispatch.
FAQ
What Cdk12 Conditional Knockout mouse models are available?
When Cdk12 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Cdk12 knockout embryonic lethal in mice?
It depends on background and allele design. Some Cdk12 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for nestin cre focused experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. Your note points to nestin cre, so we start driver selection there.
Do you ship live Cdk12 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Cdk12?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.