Cfhr1 Knockout mouse models
Cfhr1 is annotated as the mouse counterpart of human CFHR1 within the regulator of complement activation cluster syntenic to human 1q31, and encodes a secreted factor H related protein built from complement control protein modules that lack the CCP1 to CCP4 regulatory region of factor H while retaining C-terminal surface and C3b recognition modules, so it competes with factor H for host surface binding and modulates rather than executes convertase decay. Human CFHR1 also dimerizes through its N-terminal modules, and homozygous CFHR3 CFHR1 deletion associates strongly with anti-factor H autoantibody positive atypical hemolytic uremic syndrome yet is protective in age-related macular degeneration. Crucially, the murine Cfhr genes arose by independent duplication, so orthology to human CFHR1 is approximate and phenotypes rarely transfer. Full-locus humanization spanning CFH and the CFHR cluster is therefore the defensible design, with murine nulls reserved for questions about local surface competition on the mouse glomerulus.
Cfhr1 null animals are straightforward to genotype and phenotype when survival is acceptable. They remain a standard background for pharmacology, biomarker, and rescue studies.
What Cfhr1 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Cfhr1 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Cfhr1-KO | Knockout | KO/CKO mice | embryo cryopreservation | KO 190775 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Cfhr1 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Cfhr1 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Cfhr1 Knockout mouse models are available?
When Cfhr1 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Cfhr1 knockout embryonic lethal in mice?
It depends on background and allele design. Some Cfhr1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Cfhr1 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Cfhr1?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.