Col1a1 Conditional Knockout, Knockin, Knockout mouse models

Available Col1a1 catalog models

10 Col1a1 lines with QC documentation and technical support. Col1a1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

• Col1a1-Flox

  CKO

  CKO, Disease Model

  These mice carry loxP sites flanking exon 2-5 of Col1a1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Col1a1 gene.

  Sperm CryopreservedCKO 2102423
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• Col1a1-tet-DCM

  KI

  Other Toolbox (non-Cre, non-Fluorescent)

  The tet-DCM expression cassette was knocked into the Col1a1 locus.

  In DevelopmentKI 232218
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• Col1a1-tet-DCM-Polr2b

  KI

  Other Toolbox (non-Cre, non-Fluorescent)

  The tet-DCM-Polr2b expression cassette was knocked into the Col1a1 locus.

  In DevelopmentKI 232220
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• Col1a1-G516C

  KI

  Point Mutation

  These mice carry a G516C mutation of Col1a1 gene.

  In production — inquireKI 262985
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• Col1a1-IRES-CreERT2

  KI

  Cre/Dre Toolbox

  IRES-CreERT2 expression cassette was knocked into the Col1a1 gene. The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.

  LiveKI 225031
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• Col1a1-10xU6-gRNA-CAG-EGFP-Target

  KI

  Fluorescent Model, Other Toolbox (non-Cre, non-Fluorescent)

  The 10xU6-gRNA-CAG-EGFP-Target-pA expression cassette was knocked into the Col1a1 gene locus.

  LiveKI 240156
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• Col1a1-IRES-EGFP-IRES-MerCreMer

  KI

  Cre/Dre Toolbox, Fluorescent Model

  The IRES-EGFP-IRES-MerCreMer expression cassette was knocked into the Col1a1 gene stop codon site. The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.

  LiveKI 240492
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• Col1a1-TRE3G-dCas9-VPR-EGFP

  KI

  Fluorescent Model

  These mice harbor a TRE3G-dCas9-VPR(VP64-p65-Rta)-eGFP-pA tetracycline-controlled transcriptional activation cassette in mouse Col1a1 loci. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).

  Sperm CryopreservedKI 00123
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• Col1a1-KO

  KO

  KO, Disease Model

  exon 2-5 of Col1a1 gene was deleted to generate Col1a1 knockout mice.

  F0 Embryo CryopreservedKO 226315
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• Col1a1-tetO-EML4-ALK

  Other

  Other Toolbox (non-Cre, non-Fluorescent)

  The human EML4-ALK gene was cloned into a TetO-EML4-ALK construct and microinjected into FVB zygotes, where it was inserted into the mouse Col1a1 locus. This strain was donated by the laboratory of Academician Liang Chen at Jinan University. Any published research papers or other forms of literature should cite: "Zhou Q, Yang T, Yu X, et al. Lanatoside C activates the E3 ligase STUB1 to inhibit FOXP3 transcriptional activity and promote antitumor immunity. EMBO Mol Med. 2025;17(3):563-588. doi:10.1038/s44321-025-00200-y"

  Sperm CryopreservedDM KI 251860
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About Col1a1 Mouse Model Types

A Col1a1 knockout mouse has the Col1a1 gene permanently inactivated, enabling loss of function studies. A Col1a1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Col1a1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Col1a1 knockin models carry a precisely inserted sequence at the Col1a1 locus, useful for reporter, tag, or humanization studies.

Modifications available

Jump to catalog backed pages for Col1a1 organized by modification type. Each URL is indexable and matches common search patterns.

Related Gene Targets

Breed this line with ingenious targeting laboratory

Send the Col1a1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.