Des Reporter Mouse
Since 1998, ingenious targeting laboratory has delivered 2,800+ projects with 100% germline transmission guarantee and 800+ peer reviewed publications.
Des is a common request for reporter mouse models. ingenious targeting laboratory designs and delivers the line to your study specification with documented milestones.
Get a Quote in 24 HoursWhat Des Reporter mouse models are available?
ingenious targeting laboratory designs and generates Des reporter mouse models to your specification. Quotes return in about 24 hours with documented germline transmission and strict United States QC guidelines.
Scientific design
Des is a well studied locus in mouse genetics. Allele design follows your phenotype goals and what the published landscape already shows for this gene.
1 existing allele are indexed for Des, including 1 knockout. Where the published set lacks the modification you need, ingenious targeting laboratory builds that allele with documented germline transmission.
Reporter alleles fuse a detectable marker to endogenous regulation so expression mirrors the native locus. Pre germline characterization confirms signal location before germline transmission.
Quotes return in about 24 hours with milestones, pricing, and options for cryo or live dispatch.
Reporter options for Des
Des GFP reporter
Green fluorescent protein fused to Des regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Des YFP reporter
Yellow fluorescent protein fused to Des regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Des RFP reporter
Red fluorescent protein fused to Des regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Des mCherry reporter
Monomeric Cherry fluorescent protein fused to Des regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Des tdTomato reporter
Tandem dimer Tomato fused to Des regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Des lacZ reporter
Beta galactosidase reporter fused to Des regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Des Luciferase reporter
Bioluminescent reporter fused to Des regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
What researchers say
“ingenious targeting laboratory delivered exactly the floxed allele we designed, with clear milestones and germline confirmed founders.”
“The team translated our humanization requirements into a knockin strategy we could breed and phenotype on schedule.”
“Clear communication on allele design and germline transmission made our conditional knockout program straightforward to execute.”
Selected publications
- S100A4-lineage cells contribute modestly to angiotensin II-mediated thoracic aortic aneurysms through angiotensin II type 1a receptor in mice
- Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration
- SENP2 regulates UCP1-dependent thermogenesis in brown adipocytes via deSUMOylation of ERRα
- Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2
- A CRE/DRE dual recombinase transgenic mouse reveals synaptic zinc-mediated thalamocortical neuromodulation.
FAQ
What Des Reporter mouse models are available?
When Des Reporter lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Des knockout embryonic lethal in mice?
It depends on background and allele design. Some Des germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Des animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Des?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.