Foxp3 Knockin mouse models
Foxp3 defines regulatory T cell identity. Engineered mice clarified how Treg loss unleashes autoimmunity and how targeted modulation might treat cancer without catastrophic inflammation. Cre lines under Foxp3 regulatory elements are reference tools across immunology. Conditional timing experiments separate development from homeostasis in tolerance.
Knockin designs at Foxp3 support head to head comparisons between wild type and modified alleles because regulatory DNA stays in place.
Catalog table
Knockin and humanized formats preserve regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Knockin and humanized formats preserve regulatory context at the endogenous locus. For liver focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Foxp3-DreERT2 | Knockin | Cre/Dre Toolbox of Mice | sperm cryopreservation | KI 200198 | Inquire |
| Foxp3-IRES-tdTomato-2A-CreERT2 | Knockin | Cre/Dre Toolbox of Mice, fluorescent mouse | live | KI 190120 | Inquire |
| Foxp3-IRES-tdTomato-2A-Cre | Knockin | Cre/Dre Toolbox of Mice, fluorescent mouse, disease model mice | live | KI 190119 | Inquire |
| Foxp3-IRES-Luc-2A-tdTomato | Knockin | fluorescent mouse | embryo cryopreservation | KI 200065 | Inquire |
| Foxp3-IRES-DTR-2A-tdTomato(BALB/c) | Knockin | fluorescent mouse, otherToolbox of Mice(Non-Cre, fluorescent) | live | KI 200213 | Inquire |
| Foxp3-V5-AviTag-IRES-Luc-2A-tdTomato | Knockin | fluorescent mouse, otherToolbox of Mice(Non-Cre, fluorescent) | embryo cryopreservation | KI 18034 | Inquire |
| Foxp3-IRES-DTRGFP | Knockin | fluorescent mouse, otherToolbox of Mice(Non-Cre, fluorescent) | embryo cryopreservation | KI 190046 | Inquire |
Why this approach
Knockin and humanized formats preserve regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Knockin and humanized formats preserve regulatory context at the endogenous locus. For liver focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The Foxp3 Knockin lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Foxp3 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
Is Foxp3 knockout embryonic lethal in mice?
Lethality depends on genetic background and exact allele design. Some Foxp3 germline knockouts are viable, others require conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null approaches before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak patterns. We map your organ and cell type to a short list of proven Cre lines, then discuss reporter crosses and controls. We prioritize drivers with strong community validation for your tissue.
Do you ship live Foxp3 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a model generation project with cryo or live dispatch options depending on cohort timing and geography.
How do I request a quote for Foxp3?
Use the catalog inquire buttons or the request quote form with your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.