H2 Conditional Knockout mouse — K14-Cre pairing
A floxed H2 allele paired with Cre gives spatial control that whole body knockouts cannot offer. People use it to separate developmental roles from adult homeostasis, to model somatic mutations, and to match disease that begins in one organ. For skin work, plan Cre specificity, reporter crosses, and baseline phenotyping before you scale.
Catalog options
Conditional knockout focuses the experiment on skin while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
| Model | Type | Category | Availability | Catalog # | |
|---|---|---|---|---|---|
| H2-Ab1-Flox | Conditional Knockout | KO/CKO mice | live | CKO 200183 | Inquire |
| H2-T23-Flox | Conditional Knockout | KO/CKO mice | sperm cryopreservation | CKO 220482 | Inquire |
| H2-Aa-Flox | Conditional Knockout | KO/CKO mice | sperm cryopreservation | CKO 240017 | Inquire |
| H2-K1-Flox | Conditional Knockout | KO/CKO mice | sperm cryopreservation | CKO 232188 | Inquire |
Pricing and quotes
The H2 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a H2 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with milestones for genotyping, QC, and dispatch.
FAQ
What H2 Conditional Knockout mouse models are available?
When H2 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is H2 knockout embryonic lethal in mice?
It depends on background and allele design. Some H2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for k14 cre focused experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. Your note points to k14 cre, so we start driver selection there.
Do you ship live H2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for H2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Citations
- PGI2 signaling metabolically reprograms CD4 Th2 cells and represses allergic airway inflammation
- Comparative study of PRPH2 D2 loop mutants reveals divergent disease mechanism in rods and cones.
- Prph2 disease mutations lead to structural and functional defects in the RPE.
- Novel molecular mechanisms for Prph2‐associated pattern dystrophy
- Prph2 initiates outer segment morphogenesis but maturation requires Prph2/Rom1 oligomerization