H2afz Conditional Knockout mouse — Tie2-Cre pairing
Conditional deletion of H2afz limits the genetic change to the lineage you choose. That helps in oncology, immunology, and metabolic work where systemic loss would muddy the read. After you confirm Cre specificity, crossing to H2afz floxed stock yields usable cohorts. For endothelial work, plan Cre specificity, reporter crosses, and baseline phenotyping before you scale.
Driver pairing
Tie2-Cre biases toward endothelial. Inducible: no.
Catalog options
Conditional knockout focuses the experiment on endothelial while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
| Model | Type | Category | Availability | Catalog # | |
|---|---|---|---|---|---|
| H2afz-Flox | Conditional Knockout | KO/CKO mice | sperm cryopreservation | CKO 226289 | Inquire |
Pricing and quotes
The H2afz Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a H2afz allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with milestones for genotyping, QC, and dispatch.
FAQ
What H2afz Conditional Knockout mouse models are available?
When H2afz Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is H2afz knockout embryonic lethal in mice?
It depends on background and allele design. Some H2afz germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for tie2 cre focused experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. Your note points to tie2 cre, so we start driver selection there.
Do you ship live H2afz animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for H2afz?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.