Htt Conditional Knockout, Knockin, Knockout mouse models

Available Htt catalog models

3 Htt lines with QC documentation and technical support. Htt floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

• Htt-Flox

  CKO

  CKO

  These mice carry loxP sites flanking exon 5 of Htt gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Htt gene.

  Sperm CryopreservedCKO 2100397
  Order

• Htt-hHTT-Q145

  KI

  Point Mutation, Target-Humanized

  The hHTT-Q145 expression cassette was knocked into the Htt gene locus.

  Sperm CryopreservedKI 251933
  Order

• Htt-KO

  KO

  KO, Disease Model

  exon 5 of Htt gene was deleted to generate Htt knockout mice.

  F0 Embryo CryopreservedKO 226311
  Order

About Htt Mouse Model Types

A Htt knockout mouse has the Htt gene permanently inactivated, enabling loss of function studies. A Htt conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Htt, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Htt knockin models carry a precisely inserted sequence at the Htt locus, useful for reporter, tag, or humanization studies.

Modifications available

Jump to catalog backed pages for Htt organized by modification type. Each URL is indexable and matches common search patterns.

Tissue-specific options

Catalog backed tissue and driver restricted routes for Htt.

Related Gene Targets

Breed this line with ingenious targeting laboratory

Send the Htt line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.