Inhbc Knockout mouse models
Largely confined to hepatocytes, the mouse ortholog of human INHBC, Inhbc, encodes the activin beta C subunit whose homodimer, activin C, signals weakly, and whose principal documented activity is heterodimerization with beta A to divert that subunit away from bioactive activin A, effectively lowering SMAD2 and SMAD3 tone in liver and prostate. Nulls are viable without overt pathology, so the informative designs are combinatorial and gain of function rather than simple deletion: hepatocyte-directed overexpression knockins test the sequestration model directly, and conditional nulls become interpretable mainly under regenerative or injury challenge such as partial hepatectomy or hepatotoxin exposure. Humanized alleles support biochemical dissection of subunit pairing preference. Inhbe lies adjacent and is coexpressed in hepatocytes, so the locus demands care: design floxed alleles that leave neighboring regulatory elements intact, and generate compound Inhbc and Inhbe alleles when metabolic or liver injury readouts are primary.
Inhbc null animals are straightforward to genotype and phenotype when survival is acceptable. They remain a standard background for pharmacology, biomarker, and rescue studies.
What Inhbc Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Inhbc knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Inhbc-KO | Knockout | KO/CKO mice | sperm cryopreservation | KO 233847 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Inhbc Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Inhbc allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Inhbc Knockout mouse models are available?
When Inhbc Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Inhbc knockout embryonic lethal in mice?
It depends on background and allele design. Some Inhbc germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Inhbc animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Inhbc?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.