Itch Conditional Knockout Mouse
Since 1998, ingenious targeting laboratory has delivered 2,800+ projects with 100% germline transmission guarantee and 800+ peer reviewed publications.
Itch is a common request for conditional knockout mouse models. ingenious targeting laboratory designs and delivers the line to your study specification with documented milestones.
Get a Quote in 24 HoursWhat Itch Conditional Knockout mouse models are available?
ingenious targeting laboratory designs and generates Itch conditional knockout mouse models to your specification. Quotes return in about 24 hours with documented germline transmission and strict United States QC guidelines.
Scientific design
Itch is a well studied locus in mouse genetics. Allele design follows your phenotype goals and what the published landscape already shows for this gene.
1 existing allele are indexed for Itch, including 1 knockout. Where the published set lacks the modification you need, ingenious targeting laboratory builds that allele with documented germline transmission.
Conditional alleles place loxP sites around critical exons and keep reading frame intact until Cre excision. FRT flanked derivatives (tm1a to tm1c to tm1d) let you convert before breeding to your Cre driver. We confirm critical exon choice and regulatory element preservation before germline transmission.
Quotes return in about 24 hours with milestones, pricing, and options for cryo or live dispatch.
What researchers say
“ingenious targeting laboratory delivered exactly the floxed allele we designed, with clear milestones and germline confirmed founders.”
“The team translated our humanization requirements into a knockin strategy we could breed and phenotype on schedule.”
“Clear communication on allele design and germline transmission made our conditional knockout program straightforward to execute.”
Selected publications
- Jchain-diphtheria toxin receptor mice allow for depletion of antibody-secreting cells and analysis of differentiation kinetics
- Noncoding RNA transcription alters chromosomal topology to promote isotype-specific class switch recombination
- Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
- A disease mutation reveals a role for NaV1.9 in acute itch
- Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.
FAQ
What Itch Conditional Knockout mouse models are available?
When Itch Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Itch knockout embryonic lethal in mice?
It depends on background and allele design. Some Itch germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Itch animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Itch?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.