Myc Conditional Knockout mouse models
Myc is a transcriptional amplifier tied to growth programs across cancers. Mouse genetics made it possible to turn Myc dependent tumors on and off, revealing surprising regressions in some settings. Conditional control is important because constitutive misexpression is often not viable. These models inform synthetic lethality screens and rational combinations that exploit addiction rather than bulk cytotoxicity.
A floxed Myc allele paired with Cre gives spatial control that whole body knockouts cannot offer. Labs use this approach to separate developmental roles from adult homeostasis, to model human somatic mutations, and to align with clinical presentations where disease begins in one organ.
Catalog table
Conditional knockout keeps your target tissue as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Conditional knockout keeps liver as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Why this approach
Conditional knockout keeps your target tissue as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Conditional knockout keeps liver as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Myc Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Myc allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
Is Myc knockout embryonic lethal in mice?
Lethality depends on genetic background and exact allele design. Some Myc germline knockouts are viable, others require conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null approaches before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak patterns. We map your organ and cell type to a short list of proven Cre lines, then discuss reporter crosses and controls. We prioritize drivers with strong community validation for your tissue.
Do you ship live Myc animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a model generation project with cryo or live dispatch options depending on cohort timing and geography.
How do I request a quote for Myc?
Use the catalog inquire buttons or the request quote form with your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.