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Nphs2 Knockin mouse models
Targeting Nphs2 preserves positional context compared with viral or BAC approaches. That helps when you quantify expression or map chromatin.
What Nphs2 Knockin mouse models are available?
ingenious targeting laboratory offers 6 distinct Nphs2 knockin catalog mouse models. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Nphs2-CreERT2 | KI | Cre/Dre Toolbox | LIVE | KI 00128 | Inquire |
| An IRES-CreERT2 co-expression cassette is inserted into 3'UTR region of Nphs2 gene via homologous recombination to establish a tamoxifen inducible Nphs2-CreERT2 tool stain. | |||||
| Nphs2-2A-Cre | KI | Cre/Dre Toolbox | IN PRODUCTION | KI 261793 | Inquire |
| The 2A-Cre expression cassette was knocked into the Nphs2 gene stop codon site. | |||||
| Nphs2-IRES-tdTomato-2A-CreERT2(BALB/c) | KI | Cre/Dre Toolbox, Fluorescent Model | SPERM | KI 250698 | Inquire |
| The IRES-tdTomato-2A-CreERT2 expression cassette was knocked into the Nphs2 gene stop codon site. | |||||
| Nphs2-2A-Cre(BALB/c) | KI | Cre/Dre Toolbox | SPERM | KI 240824 | Inquire |
| The 2A-Cre expression cassette was knocked into the Nphs2 gene stop codon site. | |||||
| Nphs2-A286V | KI | Point Mutation, Disease Model | EMBRYO | KI 200278 | Inquire |
| These mice carry a A286V mutation of Nphs2 gene. | |||||
| Nphs2-R231Q | KI | Point Mutation, Disease Model | SPERM | KI 200277 | Inquire |
| These mice carry a R231Q mutation of Nphs2 gene. | |||||
Why this approach
Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The Nphs2 Knockin lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Nphs2 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Nphs2 Knockin mouse models are available?
When Nphs2 Knockin lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Nphs2 knockout embryonic lethal in mice?
It depends on background and allele design. Some Nphs2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Nphs2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Nphs2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Nphs2 Knockin line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.