Rag1 Conditional Knockout, Knockin, Knockout mouse models

Available Rag1 catalog models

5 Rag1 lines with QC documentation and technical support. Rag1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

• Rag1-Flox

  CKO

  CKO, Immunodeficient

  These strains carry loxP sites flanking exon 2 of Rag1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Rag1 gene.

  In production — inquireCKO 250873
  Order

• Rag1-2A-Cre

  KI

  Cre/Dre Toolbox

  2A-Cre expression cassette was knocked into the Rag1 gene stop codon site.

  Sperm CryopreservedKI 220088
  Order

• Rag1-KO(Rag1-EGFP)

  KI

  KO, Fluorescent Model, Immunodeficient, Disease Model

  A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

  LiveKI 00069
  Order

• Rag1-KO

  KO

  KO, Immunodeficient

  The exon 2 of Rag1 gene was deleted to generate Rag1 knockout mouse.

  Sperm CryopreservedKO 252600
  Order

• Rag1-KO(NOD)

  KO

  KO, Immunodeficient

  The exon 2 of Rag1 gene was deleted to generate Rag1 knockout mouse.

  LiveKO 232207
  Order

About Rag1 Mouse Model Types

A Rag1 knockout mouse has the Rag1 gene permanently inactivated, enabling loss of function studies. A Rag1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Rag1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Rag1 knockin models carry a precisely inserted sequence at the Rag1 locus, useful for reporter, tag, or humanization studies.

Modifications available

Jump to catalog backed pages for Rag1 organized by modification type. Each URL is indexable and matches common search patterns.

Related Gene Targets

Breed this line with ingenious targeting laboratory

Send the Rag1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.