Rag2 Conditional Knockout, Humanized, Knockin mouse models

Available Rag2 catalog models

17 Rag2 lines with QC documentation and technical support. Rag2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout. Rag2 humanized models carry the human gene sequence for translational research.

• Rag2-Flox

  CKO

  CKO, Immunodeficient

  These strains carry loxP sites flanking exon 3 of Rag2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Rag2 gene.

  Sperm CryopreservedCKO 233037
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• Rag2-KO/hTROP2

  HU

  KO, Target-Humanized, Immunodeficient

  The hTACSTD2(HU 215022) was crossed with Rag2-KO(KO 190429) to generate Rag2-KO/hTACSTD2 mice.

  LiveHU 234872
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• Rag2-KO/hHER2

  HU

  KO, Target-Humanized, Immunodeficient

  The hHER2(HU 200115) was crossed with Rag2-KO(KO 190429) to generate Rag2-KO/hHER2 mice.

  Embryo CryopreservedHU 234873
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• Rag2-KO/hVEGFR2

  HU

  KO, Target-Humanized, Immunodeficient

  The Rag2 gene of HU 00098 was knock out.

  Embryo CryopreservedHU 200280
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• Rag2-KO(Rag2-EGFP)

  KI

  KO, Fluorescent Model, Immunodeficient, Disease Model

  A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

  Embryo CryopreservedKI 00070
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• Rag2-KO(FVB)

  KO

  KO, Immunodeficient

  The exon3 of Rag2 gene was deleted to generate Rag2 knockout mouse.

  Sperm CryopreservedKO 233033
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• Rag2-KO/hVEGFA

  KO

  KO, Target-Humanized, Immunodeficient

  hVEGFA(HU 2000028) was crossed with Rag2-KO（KO 190429）to generate Rag2-KO/hVEGFA.

  Embryo CryopreservedKO 220639
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• Rag2-KO

  KO

  KO, Immunodeficient, Disease Model

  Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

  LiveKO 190429
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• Rag2-KO(NOD)

  KO

  KO, Immunodeficient

  The exon 3 of Rag2 gene was deleted to generate Rag2 knockout mouse.

  Sperm CryopreservedKO 232209
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• Rag2-KO/hVEGFA(2)

  XA

  KO, Target-Humanized, Immunodeficient

  The hVEGFA(2)(HU 204984) was crossed with Rag2-KO(KO 190429) to generate Rag2-KO/hVEGFA mice.

  Embryo CryopreservedXA 240494
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• Rag2-KO/hFCRN(2)

  XA

  Target-Humanized

  The hFCRN(2) (HU 190070) was crossed with Rag2-KO(KO 190429) to generate hFCRN(2)/Rag2-KO mice.

  In DevelopmentXA 262616
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• Rag2-KO/hIL12B/hIL23A/hTL1A(3)

  XA

  KO, Target-Humanized

  The hIL12B/hIL23A/hTL1A(3) (XA 252106) was crossed with Rag2-KO(KO 190429) to generate hIL12B/hIL23A/hTL1A(3)/Rag2-KO mice.

  In DevelopmentXA 260606
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• Rag2-KO/hCRBN

  XA

  KO, Target-Humanized, Immunodeficient

  The hCRBN (HU 225071) was crossed with Rag2-KO(KO 190429) to generate hCRBN/Rag2-KO mice.

  LiveXA 251818
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• Rag2-KO/hENG

  XA

  KO, Target-Humanized, Immunodeficient

  The hENG(HU 220283) was crossed with Rag2-KO(KO 190429) to generate Rag2-KO/hENG mice.

  LiveXA 250917
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• Rag2-KO/hEPCAM

  XA

  KO, Target-Humanized, Immunodeficient

  The hEPCAM(HU 210032) was crossed with Rag2-KO(KO 190429) to generate Rag2-KO/hEPCAM mice.

  Embryo CryopreservedXA 250604
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• Rag2-KO/pMMTV-Erbb2*V664E-Tg(FVB)

  XA

  KO, Point Mutation, Immunodeficient, Random Transgenic

  The Rag2-KO(FVB)(KO 233033) was crossed with pMMTV-Erbb2*V664E-Tg(FVB)(TG 220194) to generate Rag2-KO/pMMTV-Erbb2*V664E-Tg(FVB) mice.

  Not DevelopedXA 241615
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• Rag2-KO/hFCRN(3)

  XA

  Target-Humanized

  The hFCRN(3) (HU 2000032) was crossed with Rag2-KO(KO 190429) to generate hFCRN(3)/Rag2-KO mice.

  In DevelopmentXA 262617
  Order

About Rag2 Mouse Model Types

A Rag2 knockout mouse has the Rag2 gene permanently inactivated, enabling loss of function studies. A Rag2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Rag2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Rag2 knockin models carry a precisely inserted sequence at the Rag2 locus, useful for reporter, tag, or humanization studies. A Rag2 humanized mouse replaces the mouse Rag2 gene with the human ortholog for translational research and drug development.

Modifications available

Jump to catalog backed pages for Rag2 organized by modification type. Each URL is indexable and matches common search patterns.

Related Gene Targets

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Send the Rag2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.