She Knockout Mouse
Since 1998, ingenious targeting laboratory has delivered 2,800+ projects with 100% germline transmission guarantee and 800+ peer reviewed publications.
She is a common request for knockout mouse models. Ingenious targeting laboratory designs and delivers the line to your study specification with documented milestones.
Get a Quote in 24 HoursWhat She Knockout mouse models are available?
ingenious targeting laboratory designs and generates She knockout mouse models to your specification. Quotes return in about 24 hours with documented germline transmission and strict United States QC guidelines.
Scientific design
She is a well studied locus in mouse genetics. Allele design follows your phenotype goals and what the published landscape already shows for this gene.
1 existing allele are indexed for She, including 1 conditional. Where the published set lacks the modification you need, ingenious targeting laboratory builds that allele with documented germline transmission.
Knockout alleles remove or disrupt coding sequence using gene targeting. Critical exon selection and frame considerations are confirmed before microinjection so founders carry a defined null or hypomorphic allele.
Quotes return in about 24 hours with milestones, pricing, and options for cryo or live dispatch.
What researchers say
“Ingenious targeting laboratory delivered exactly the floxed allele we designed, with clear milestones and germline confirmed founders.”
“The team translated our humanization requirements into a knockin strategy we could breed and phenotype on schedule.”
“Clear communication on allele design and germline transmission made our conditional knockout program straightforward to execute.”
Selected publications
- Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling
- OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage
- Expression of the human usherin c.2299delG mutation leads to early-onset auditory loss and stereocilia disorganization
- Spontaneous Mutation in 2310061I04Rik Results in Reduced Expression of Mitochondrial Genes and Impaired Brain Myelination.
- The usherin mutation c.2299delG leads to its mislocalization and disrupts interactions with whirlin and VLGR1.
FAQ
What She Knockout mouse models are available?
When She Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is She knockout embryonic lethal in mice?
It depends on background and allele design. Some She germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live She animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for She?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.