Stk19 Conditional Knockout mouse — Cdx2-CreERT2 pairing
Tissue restricted knockout of Stk19 reduces off target stress compared with constitutive loss. You retain wild type Stk19 everywhere else, which improves breeding robustness and mirrors patient biology where mutations arise in a subset of cells. For intestinal work, plan Cre specificity, reporter crosses, and baseline phenotyping before you scale.
Driver pairing
Cdx2-CreERT2 biases toward intestinal. Inducible: yes (tamoxifen).
Catalog options
Conditional knockout keeps intestine as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
| Model | Type | Category | Availability | Catalog # | |
|---|---|---|---|---|---|
| Stk19-Flox | Conditional Knockout | KO/CKO mice | sperm cryopreservation | CKO 234393 | Inquire |
Why this approach
Conditional knockout keeps neuron as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Stk19 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Stk19 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with milestones for genotyping, QC, and dispatch.
FAQ
Is Stk19 knockout embryonic lethal in mice?
Lethality depends on genetic background and exact allele design. Some Stk19 germline knockouts are viable, others require conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null approaches before you commit.
Which Cre driver is best for cdx2 creert2 focused experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak patterns. We map your organ and cell type to a short list of proven Cre lines, then discuss reporter crosses and controls. Your query highlights cdx2 creert2 as a primary axis, which we treat as the starting point for driver selection.
Do you ship live Stk19 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a model generation project with cryo or live dispatch options depending on cohort timing and geography.
How do I request a quote for Stk19?
Use the catalog inquire buttons or the request quote form with your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.