Tox Reporter Mouse
Since 1998, ingenious targeting laboratory has delivered 2,800+ projects with 100% germline transmission guarantee and 800+ peer reviewed publications.
Tox is a common request for reporter mouse models. ingenious targeting laboratory designs and delivers the line to your study specification with documented milestones.
Get a Quote in 24 HoursWhat Tox Reporter mouse models are available?
ingenious targeting laboratory designs and generates Tox reporter mouse models to your specification. Quotes return in about 24 hours with documented germline transmission and strict United States QC guidelines.
Scientific design
Tox is a well studied locus in mouse genetics. Allele design follows your phenotype goals and what the published landscape already shows for this gene.
1 existing allele are indexed for Tox, including 1 knockout. Where the published set lacks the modification you need, ingenious targeting laboratory builds that allele with documented germline transmission.
Reporter alleles fuse a detectable marker to endogenous regulation so expression mirrors the native locus. Pre germline characterization confirms signal location before germline transmission.
Quotes return in about 24 hours with milestones, pricing, and options for cryo or live dispatch.
Reporter options for Tox
Tox GFP reporter
Green fluorescent protein fused to Tox regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Tox YFP reporter
Yellow fluorescent protein fused to Tox regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Tox RFP reporter
Red fluorescent protein fused to Tox regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Tox mCherry reporter
Monomeric Cherry fluorescent protein fused to Tox regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Tox tdTomato reporter
Tandem dimer Tomato fused to Tox regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Tox lacZ reporter
Beta galactosidase reporter fused to Tox regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Tox Luciferase reporter
Bioluminescent reporter fused to Tox regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
What researchers say
“ingenious targeting laboratory delivered exactly the floxed allele we designed, with clear milestones and germline confirmed founders.”
“The team translated our humanization requirements into a knockin strategy we could breed and phenotype on schedule.”
“Clear communication on allele design and germline transmission made our conditional knockout program straightforward to execute.”
Selected publications
- Jchain-diphtheria toxin receptor mice allow for depletion of antibody-secreting cells and analysis of differentiation kinetics
- PD-1 prelimits both the cytotoxic and exhaustion potential in thymic CD8+ T cells and impacts the maintenance of peripheral tumor immunity
- Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia.
- HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity.
- Cytotoxic granule endocytosis depends on the Flower protein.
FAQ
What Tox Reporter mouse models are available?
When Tox Reporter lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Tox knockout embryonic lethal in mice?
It depends on background and allele design. Some Tox germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Tox animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Tox?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.