Trp53 Xenograft-Applicable mouse models
Trp53 is the guardian of the genome. Stress signals push this tumor suppressor toward cell cycle arrest, senescence, or apoptosis, so the pathway sits at the center of cancer biology. Mouse models let you test somatic mutation timing, cooperation with Kras or Myc, and therapeutic windows in DNA damage driven disease. Conditional alleles matter because complete loss can reshape development while adult onset deletion better mirrors human oncology. Humanized and point mutant variants support antibody and small molecule programs where epitope fidelity matters.
Work with your strain choice to align human tumor models with the immune profile you need.
Catalog table
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For your target tissue centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For liver centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Trp53-Flox/Kras-LSL-G12D/Alb-Cre-Tg(NMX) | Xenograft-Applicable | KO/CKO mice,point mutantion mice,Cre/Dre Toolbox of Mice, random transgenic mice | live | XA 251927 | Inquire |
| Trp53-Flox/Stk11-Flox/Kras-LSL-G12D | Xenograft-Applicable | KO/CKO mice,point mutantion mice | embryo cryopreservation | XA 250002 | Inquire |
| Trp53-Flox/Alb-Cre-Tg(NMX) | Xenograft-Applicable | KO/CKO mice,Cre/Dre Toolbox of Mice, random transgenic mice | live | XA 252654 | Inquire |
| Trp53-Flox/R26-CreERT2 | Xenograft-Applicable | KO/CKO mice,Cre/Dre Toolbox of Mice | live | XA 251497 | Inquire |
| Trp53-Flox/Pten-Flox/Pbsn-2A-CreERT2 | Xenograft-Applicable | KO/CKO mice,Cre/Dre Toolbox of Mice | live | XA 242164 | Inquire |
| Trp53-Flox/Pten-Flox | Xenograft-Applicable | KO/CKO mice | live | XA 241867 | Inquire |
Why this approach
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For your target tissue centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For liver centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
Build timeline and pricing
Typical custom projects target study ready cohorts near twenty six weeks from contract start when breeding is direct. Quotes return in about twenty four hours with milestones, pricing, and options for cryo or live dispatch.
Open the request quote formFAQ
How long does a Trp53 xenograft-applicable project take?
Most custom xenograft-applicable projects run near twenty six weeks from contract activation to study ready animals when breeding is straightforward. Complex humanization or multi allele stacks can add time. We return detailed quotes within about twenty four hours so you can align cohort start dates with grant or IND milestones.
Is Trp53 knockout embryonic lethal in mice?
Lethality depends on genetic background and exact allele design. Some Trp53 germline knockouts are viable, others require conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null approaches before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak patterns. We map your organ and cell type to a short list of proven Cre lines, then discuss reporter crosses and controls. We prioritize drivers with strong community validation for your tissue.
Do you ship live Trp53 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a custom project with cryo or live dispatch options depending on cohort timing and geography.
How do I request a quote for Trp53?
Use the catalog inquire buttons or the request quote form with your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.