Ttl Reporter Mouse
Since 1998, ingenious targeting laboratory has delivered 2,800+ projects with 100% germline transmission guarantee and 800+ peer reviewed publications.
Ttl is a common request for reporter mouse models. ingenious targeting laboratory designs and delivers the line to your study specification with documented milestones.
Get a Quote in 24 HoursWhat Ttl Reporter mouse models are available?
ingenious targeting laboratory designs and generates Ttl reporter mouse models to your specification. Quotes return in about 24 hours with documented germline transmission and strict United States QC guidelines.
Scientific design
Ttl is a well studied locus in mouse genetics. Allele design follows your phenotype goals and what the published landscape already shows for this gene.
1 existing allele are indexed for Ttl, including 1 conditional. Where the published set lacks the modification you need, ingenious targeting laboratory builds that allele with documented germline transmission.
Reporter alleles fuse a detectable marker to endogenous regulation so expression mirrors the native locus. Pre germline characterization confirms signal location before germline transmission.
Quotes return in about 24 hours with milestones, pricing, and options for cryo or live dispatch.
Reporter options for Ttl
Ttl GFP reporter
Green fluorescent protein fused to Ttl regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Ttl YFP reporter
Yellow fluorescent protein fused to Ttl regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Ttl RFP reporter
Red fluorescent protein fused to Ttl regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Ttl mCherry reporter
Monomeric Cherry fluorescent protein fused to Ttl regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Ttl tdTomato reporter
Tandem dimer Tomato fused to Ttl regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Ttl lacZ reporter
Beta galactosidase reporter fused to Ttl regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
Ttl Luciferase reporter
Bioluminescent reporter fused to Ttl regulatory elements reports native expression. ingenious targeting laboratory engineers the knockin and confirms pattern before germline transmission.
What researchers say
“ingenious targeting laboratory delivered exactly the floxed allele we designed, with clear milestones and germline confirmed founders.”
“The team translated our humanization requirements into a knockin strategy we could breed and phenotype on schedule.”
“Clear communication on allele design and germline transmission made our conditional knockout program straightforward to execute.”
Selected publications
- RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition
- GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
- Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility.
- Age-related changes in Cngb1-X1 knockout mice: prolonged cone survival.
- Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.
FAQ
What Ttl Reporter mouse models are available?
When Ttl Reporter lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Ttl knockout embryonic lethal in mice?
It depends on background and allele design. Some Ttl germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Ttl animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Ttl?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.