Was Humanized Mouse
Since 1998, ingenious targeting laboratory has delivered 2,800+ projects with 100% germline transmission guarantee and 800+ peer reviewed publications.
Was is a common request for humanized mouse models. ingenious targeting laboratory designs and delivers the line to your study specification with documented milestones.
Get a Quote in 24 HoursWhat Was Humanized mouse models are available?
ingenious targeting laboratory designs and generates Was humanized mouse models to your specification. Quotes return in about 24 hours with documented germline transmission and strict United States QC guidelines.
Scientific design
Was is a well studied locus in mouse genetics. Allele design follows your phenotype goals and what the published landscape already shows for this gene.
1 existing allele are indexed for Was, including 1 knockout. Where the published set lacks the modification you need, ingenious targeting laboratory builds that allele with documented germline transmission.
Humanization replaces mouse coding sequence with human ortholog sequence at the endogenous locus while keeping native regulatory context. Gene targeting documents junctions and expression before germline transmission.
Human ortholog WAS guides humanization design so human coding sequence replaces the mouse exons under endogenous control.
Quotes return in about 24 hours with milestones, pricing, and options for cryo or live dispatch.
What researchers say
“ingenious targeting laboratory delivered exactly the floxed allele we designed, with clear milestones and germline confirmed founders.”
“The team translated our humanization requirements into a knockin strategy we could breed and phenotype on schedule.”
“Clear communication on allele design and germline transmission made our conditional knockout program straightforward to execute.”
Selected publications
- Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration
- GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
- Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive
- Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility.
FAQ
What Was Humanized mouse models are available?
When Was Humanized lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Was knockout embryonic lethal in mice?
It depends on background and allele design. Some Was germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Was animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Was?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.