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hCTLA Humanized mouse models
hCTLA humanization is common when the therapeutic is a human specific antibody or small molecule with species selectivity.
What hCTLA Humanized mouse models are available?
ingenious targeting laboratory offers 10 distinct hCTLA humanized catalog mouse models. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| hCTLA-4(2) | HU | Target-Humanized | EMBRYO | HU 190038 | Inquire |
| Extracellular domain of mouse Ctla4 gene was replaced by human CTLA4 gene. While hCTLA4(Stock No.HU 00014) mice function similarly to hCTLA4(2) mice,for more detailed information please contact our technical advisor. | |||||
| hCTLA-4(BALB/c) | HU | Target-Humanized | EMBRYO | HU 190078 | Inquire |
| Obtained by backcrossing of HU 00014，hCTLA-4 mice. | |||||
| hCTLA-4 | HU | Target-Humanized | LIVE | HU 00014 | Inquire |
| The endogenous mouse Ctal4 gene was replaced by human CTLA4 gene. While hCTLA4(2)(Stock No.HU 190038) mice function similarly to hCTLA4 mice,for more detailed information please contact our technical advisor. | |||||
| hCTLA-4/hIL2RA | HU | Target-Humanized | EMBRYO | HU 233159 | Inquire |
| The hIL2RA(HU 190064) was crossed with hCTLA-4(HU 00014) to generate hCTLA-4/hIL2RA mice. | |||||
| hCTLA-4/hCD28(BALB/c) | HU | Target-Humanized | SPERM | HU 200226 | Inquire |
| The endogenous mice Ctla4 and Cd28 gene was replaced by human CTLA4 and CD28 gene. | |||||
| hCTLA-4/hCCR8(BALB/c,2) | HU | Target-Humanized | LIVE | HU 234064 | Inquire |
| The hCCR8(BALB/c)(2)(HU 220501) was crossed with hCTLA-4(BALB/c)(HU 190078) to generate hCTLA-4/hCCR8(BALB/c,2) mice. | |||||
| hCTLA-4/h4-1BB(2) | HU | Target-Humanized | EMBRYO | HU 210355 | Inquire |
| hCTLA4(HU 00014) was crossed with h4-1BB(2)(HU 190077）to generate hCTLA4/h4-1BB(2) mice. | |||||
| hCTLA-4/Cd8a-IRES-Luc-2A-EGFP | HU | Fluorescent Model, Target-Humanized | EMBRYO | HU 210374 | Inquire |
| hCTLA4(HU 00014) was crossed with Cd8a-IRES-Akaluc-2A-EGFP(KI 18030) to generate hCTLA4/Cd8a-IRES-Akaluc-2A-EGFP mice. | |||||
| hCTLA-4/hCCR8(BALB/c) | HU | Target-Humanized | EMBRYO | HU 220050 | Inquire |
| hCTLA4(BALB/c)(HU 190078) was crossed with hCCR8(BALB/c)(HU 2000048) to generate hCTLA4/hCCR8(BALB/c) mice． | |||||
| hCTLA-4/hTIGIT | HU | Target-Humanized | EMBRYO | HU 210399 | Inquire |
| hCTLA4(HU 00014) was crossed with hTIGIT(HU 00053) to generate hCTLA4/hTIGIT mice. | |||||
Why this approach
Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The hCTLA Humanized lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a hCTLA allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What hCTLA Humanized mouse models are available?
When hCTLA Humanized lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is hCTLA knockout embryonic lethal in mice?
It depends on background and allele design. Some hCTLA germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live hCTLA animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for hCTLA?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Related models and routes
Breed this line with ingenious targeting laboratory
Send the hCTLA Humanized line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.