hHLA Humanized mouse models
These models bridge mouse genetics with translational readouts on human biology at the hHLA locus.
What hHLA Humanized mouse models are available?
ingenious targeting laboratory offers 5 distinct hHLA humanized catalog mouse models. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| hHLA-E | Humanized | Target humanized mice | embryo cryopreservation | HU 200221 | Inquire |
| hHLA-DPB1*04: 01 | Humanized | Target humanized mice | sperm cryopreservation | HU 210011 | Inquire |
| hHLA-A2.22 | Humanized | Target humanized mice | live | HU 204988 | Inquire |
| hHLA-DPA1*03: 01 | Humanized | Target humanized mice | live | HU 210009 | Inquire |
| hHLA-A11.1 | Humanized | Target humanized mice, disease model mice | live | HU 204987 | Inquire |
Why this approach
Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The hHLA Humanized lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a hHLA allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What hHLA Humanized mouse models are available?
When hHLA Humanized lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is hHLA knockout embryonic lethal in mice?
It depends on background and allele design. Some hHLA germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live hHLA animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for hHLA?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.