AGT Mouse Models

Why Model AGT

Agt is the mouse ortholog of human AGT and encodes angiotensinogen, a secreted precursor of the renin-angiotensin system produced mainly by the liver. Angiotensinogen is cleaved by renin to generate angiotensin I and has been associated with regulation of blood pressure and fluid balance.

The renin-angiotensin system is central to blood-pressure regulation, and angiotensinogen is targeted by RNA-interference approaches under study for hypertension. Agt-deficient mice show low blood pressure and kidney abnormalities.

Model Applications

Humanized AGT models, in which the human protein replaces the mouse counterpart, have been used to evaluate angiotensinogen-directed agents in defined experimental settings.

Custom AGT Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• RNA interference with zilebesiran for mild to moderate hypertension. JAMA. 2024. doi:10.1001/jama.2024.0728
• Kunapuli SP, Kumar A. Molecular cloning of human angiotensinogen cDNA and evidence for the presence of its mRNA in rat heart. Circ Res. 1987. doi:10.1161/01.res.60.5.786

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Ren1 · Ace · Agtr1a · Agtr2