AGTR1 Mouse Models

Why Model AGTR1

AGTR1 (mouse ortholog Agtr1a, with a related Agtr1b) encodes the angiotensin II type 1 receptor (AT1), a class A G-protein-coupled receptor. AT1 signaling in response to angiotensin II has been associated with vasoconstriction and regulation of blood pressure and fluid balance.

The AT1 receptor is the target of angiotensin-receptor blockers used widely in hypertension and cardiovascular and kidney disease. Mice lacking AT1 receptors show low blood pressure and kidney changes.

Model Applications

Humanized AGTR1 models, in which the human receptor replaces the mouse counterpart, have been used to evaluate AT1-receptor-directed agents in defined experimental settings.

Custom AGTR1 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Association of the angiotensin II type 1 receptor A1166C polymorphism with essential hypertension: a meta-analysis with ethnic and geographic subgroup analyses. Blood Press. 2026. doi:10.1080/08037051.2026.2676370
• Murphy TJ et al. Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature. 1991. doi:10.1038/351233a0

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Agt · Ren1 · Agtr2 · Ace