REN Mouse Models

Why Model REN

REN encodes renin, an aspartyl protease secreted mainly by the kidney; mouse strains carry one or two renin genes (Ren1, Ren2). Renin cleaves angiotensinogen to generate angiotensin I and has been associated with the rate-limiting step of the renin-angiotensin system.

The renin-angiotensin system is central to blood-pressure and fluid regulation, and renin and its pathway are targeted by several antihypertensive therapies. Mice with altered renin genes show changes in blood pressure and kidney physiology.

Model Applications

Humanized REN models, in which the human gene replaces the mouse counterpart, have been used to study renin biology and to evaluate renin-system-directed agents in defined experimental settings.

Custom REN Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• The emerging role of aldosterone synthase inhibitors in overcoming renin-angiotensin-aldosterone system therapy limitations: a narrative review. Card Fail Rev. 2025. doi:10.15420/cfr.2025.09
• Imai T et al. Cloning and sequence analysis of cDNA for human renin precursor. Proc Natl Acad Sci U S A. 1983. doi:10.1073/pnas.80.24.7405

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Agt · Ace · Agtr1a · Kng1