APLNR Mouse Models

Why Model APLNR

Aplnr is the mouse ortholog of human APLNR and encodes the apelin receptor (APJ), a class A G-protein-coupled receptor that binds the peptides apelin and ELABELA/Toddler. APLNR signaling has been associated with cardiovascular function and fluid homeostasis.

The apelin-APLNR system has been studied as a target in heart failure, pulmonary hypertension, and other cardiovascular conditions. Aplnr-deficient mice show cardiovascular and developmental phenotypes.

Model Applications

Humanized APLNR models, in which the human receptor replaces the mouse counterpart, have been used to evaluate apelin-receptor-directed agents in defined experimental settings.

Custom APLNR Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Apelin receptor pharmacology in the human cardiovascular system and emerging clinical applications. Pharmacol Rev. 2026. doi:10.1016/j.pharmr.2026.100130
• O’Dowd BF et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene. 1993. doi:10.1016/0378-1119(93)90495-o

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Apln · Apela · Agtr1a · Gnai1