App Mouse Models

Why Model App

App is the mouse ortholog of human APP and encodes the amyloid precursor protein, a transmembrane protein processed by secretases. Sequential cleavage of APP generates amyloid-β peptides, which have been associated with amyloid plaque formation in Alzheimer’s disease.

Mutations in APP and altered amyloid-β processing are linked to familial Alzheimer’s disease, and the amyloid hypothesis has guided much research, though disease mechanisms remain under study. Humanized and knock-in App alleles have been developed to study amyloid biology.

Model Applications

Humanized App knock-in models, including alleles carrying familial Alzheimer’s disease mutations, express humanized amyloid-β from the endogenous locus and have been used to investigate amyloid pathology without APP overexpression.

These models have been used to study disease-relevant mechanisms and to evaluate amyloid-targeted approaches in defined experimental settings.

Custom App Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Alzheimer’s disease: a comprehensive review of epidemiology, risk factors, pathophysiology, and management. Front Med (Lausanne). 2024. doi:10.3389/fmed.2024.1474043
• Saito T et al. Single App knock-in mouse models of Alzheimer’s disease. Nat Neurosci. 2014. doi:10.1038/nn.3697
• Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science. 2002. doi:10.1126/science.1072994
• Kang J et al. The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor. Nature. 1987. doi:10.1038/325733a0

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Psen1 · Psen2 · Mapt · Apoe