Conventional / global / constitutive KO
●2 Models Available
App Conditional Knockout, Knockout mouse models
Browse 2 App mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as App conditional knockout mouse, App knockout mouse. Request a quote within 24 hours.
Why model App
App encodes amyloid precursor protein, the mouse ortholog of human APP, a type I transmembrane glycoprotein with E1 and E2 ectodomain modules that is either cleaved by ADAM10 within the Aβ sequence, precluding amyloid, or processed sequentially by BACE1 and the presenilin-containing γ-secretase complex to liberate Aβ40, Aβ42 and the AICD transcriptional fragment. Familial Alzheimer alleles act by shifting that competition: Swedish KM670/671NL enhances BACE1 cleavage, London V717I raises the Aβ42 to Aβ40 ratio, Arctic E22G accelerates protofibril assembly, and Icelandic A673T is protective. Rodent Aβ differs from human at three residues (Arg5, Tyr10, His13) and aggregates poorly, so humanizing the Aβ-coding exons in place, rather than transgenic overexpression, is the design that preserves endogenous promoter control and copy number. Aplp1 and Aplp2 compensate broadly, and App with Aplp2 double nulls die perinatally, so plan compound genetics when synaptic and neuromuscular endpoints accompany plaque and cerebral amyloid angiopathy readouts.
What App mouse models are available?
ingenious targeting laboratory offers 2 distinct App (APP) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
App model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
App allele types
Knockout, conditional, knockin, humanized, and related paths for App (human APP). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available App catalog models
2 App lines with QC documentation and technical support. App floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving App (APP) from ITL supported projects.
- Spatial Mapping of CoQ10 Repletion by BPM31510 in a Genetic Mouse Model (Coq4F147C) of Coenzyme Q DeficiencyBarriocanal-Casado E, Stopka SA, Pesini A, Aristizabal-Henao JJ, Karmacharya S, Van Cura D, Zhang R, Nickerson KR, Grover K, Zavidij O, Wessel SR, Narain NR, Modur V, Gesta S, Kiebish MA, Quinzii CM. (2026). J Lipid Res. 3(67): 100987
- Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic NeurodegenerationJiang Y, Sachdeva K, Goulbourne CN, Berg MJ, Peddy J, Stavrides PH, Pensalfini A, Pawlik M, Malampati S, Whyte L, Basavarajappa BS, Shivakumar S, Bleiwas C, Smiley JF, Mathews PM, Nixon RA. (2025). . J Neurosci 29(45): e2331242025.
- Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responsesAdelaja A, Taylor B, Sheu KM, Liu Y, Luecke S, Hoffmann A. (2021). Immunity 54(5): 916-930.e7
- Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer’s DiseasePark G, Nhan HS, Tyan SH, Kawakatsu Y, Zhang C, Navarro M, Koo EH. (2020). Cell Rep 31(13): 107839
- Multi-image color refinement with application to disparity estimationBishop, TE. (2018). US Patent No.10,097,805 B2
Looking for a App mouse model?
We have 2 App models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About App Mouse Model Types
A App knockout mouse has the App gene permanently inactivated, enabling loss of function studies. A App conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of App, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for App organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for App.