ASGR1 Mouse Models

Why Model ASGR1

Asgr1 is the mouse ortholog of human ASGR1 and encodes the major subunit of the asialoglycoprotein receptor, a C-type lectin on hepatocytes that binds galactose- and N-acetylgalactosamine-terminated glycoproteins and mediates their uptake. ASGR1 has been associated with clearance of desialylated glycoproteins.

ASGR1 is used for liver-targeted drug delivery (for example, GalNAc-conjugated therapeutics), and loss-of-function ASGR1 variants have been associated with lower non-HDL cholesterol and cardiovascular risk. Asgr1-deficient mice show altered glycoprotein clearance.

Model Applications

Humanized ASGR1 models, in which the human receptor replaces the mouse counterpart, have been used to evaluate ASGR1-targeted delivery and agents in defined experimental settings.

Custom ASGR1 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Hepatocyte targeting via the asialoglycoprotein receptor. RSC Med Chem. 2024. doi:10.1039/d4md00652f
• Spiess M, Lodish HF. Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution. Proc Natl Acad Sci U S A. 1985. doi:10.1073/pnas.82.19.6465

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Asgr2 · Lrp1 · Ldlr · Mrc1