Cd19 Mouse Models

Why Model Cd19

Cd19 is the mouse ortholog of human CD19 and encodes CD19, a B-lymphocyte surface protein of the immunoglobulin superfamily that functions as part of a B-cell co-receptor complex. CD19 has been associated with modulation of B-cell receptor signaling and B-cell development.

CD19 is expressed across most B-cell malignancies, and CD19-directed CAR T cells and antibodies are used in certain B-cell cancers; responses and durability vary. Cd19-deficient mice are viable and show impaired B-cell responses.

Model Applications

Humanized CD19 models, in which the human protein replaces the mouse counterpart, have been used to evaluate CD19-directed therapeutics, including CAR T cells and antibodies, in immunocompetent mice.

Cd19 knockout mice have been used to study B-cell signaling and development.

Custom Cd19 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Outcome correlates of approved CD19-targeted CAR T cells for large B cell lymphoma. Nat Rev Clin Oncol. 2025. doi:10.1038/s41571-025-00992-5
• Maude SL et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med. 2014. doi:10.1056/NEJMoa1407222
• Tedder TF, Isaacs CM. Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. J Immunol. 1989. doi:10.4049/jimmunol.143.2.712

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Ms4a1 · Cd79a · Cd79b · Cr2