Ms4a1 Mouse Models

Why Model Ms4a1

Ms4a1 is the mouse ortholog of human MS4A1 and encodes CD20, a membrane protein of the MS4A family expressed on B lymphocytes from the pre-B through mature stages. CD20 has been associated with roles in B-cell activation and calcium signaling.

CD20 is a target of antibody therapy in B-cell lymphomas, leukemias, and some autoimmune diseases, and several anti-CD20 antibodies are in clinical use. Ms4a1-deficient mice are viable and show largely preserved B-cell development with altered responses in some settings.

Model Applications

Humanized MS4A1 (CD20) models, in which the human protein replaces the mouse counterpart, have been used to evaluate anti-CD20 antibodies and CD20-directed cell therapies in immunocompetent mice.

Ms4a1 models have been used to study CD20 biology in defined experimental settings.

Custom Ms4a1 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Advancements in cancer immunotherapies targeting CD20: from pioneering monoclonal antibodies to chimeric antigen receptor-modified T cells. Front Immunol. 2024. doi:10.3389/fimmu.2024.1363102
• Tedder TF et al. Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci U S A. 1988. doi:10.1073/pnas.85.1.208

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Cd19 · Cd79a · Cd79b · Ms4a2