CD22 Mouse Models
| Field | Value |
|---|---|
| Mouse symbol | Cd22 |
| Human ortholog | CD22 |
| Aliases | Siglec-2, BL-CAM |
| Protein class | Ig-superfamily sialic-acid-binding receptor (Siglec-2) |
| Location (human) | 19q13.12 |
| Mouse gene (MGI) | MGI:88322 |
| Human gene | HGNC:1643 · NCBI Gene 933 |
Why Model CD22
Cd22 is the mouse ortholog of human CD22 and encodes CD22 (Siglec-2), an immunoglobulin-superfamily sialic-acid-binding receptor expressed on B cells. CD22 has been associated with regulation of B-cell receptor signaling.
CD22 is expressed across most B-cell malignancies, and CD22-directed agents, including an antibody–drug conjugate and CAR T cells, are used or under study. Cd22-deficient mice are viable with altered B-cell responses.
Model Applications
Humanized CD22 models, in which the human protein replaces the mouse counterpart, have been used to evaluate CD22-directed therapeutics in defined experimental settings.
Custom CD22 Model Options
Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.
- Conventional knockout
- Conditional knockout
- Point mutation / knockin
- Reporter knockin
- Humanized
- Targeted transgenic
Sources
- CD22-directed CAR T-cell therapy for large B-cell lymphomas progressing after CD19-directed CAR T-cell therapy: a dose-finding phase 1 study. Lancet. 2024. doi:10.1016/s0140-6736(24)00746-3
- Stamenkovic I, Seed B. The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. Nature. 1990. doi:10.1038/345074a0
Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele
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