Cd38 Mouse Models

Why Model Cd38

Cd38 is the mouse ortholog of human CD38 and encodes CD38, a cell-surface glycoprotein with ectoenzyme activity involved in the metabolism of NAD+ and cyclic ADP-ribose. CD38 is expressed on plasma cells and various immune cells and has been associated with roles in calcium signaling and cell adhesion.

CD38 is highly expressed on malignant plasma cells in multiple myeloma, and CD38-directed antibodies are used in that disease, often combined with other agents; responses vary. Cd38-deficient mice are viable and show altered immune and metabolic responses.

Model Applications

Humanized CD38 models, in which the human protein replaces the mouse counterpart, have been used to evaluate anti-CD38 antibodies in immunocompetent mice.

Cd38 knockout mice have been used to study NAD+ metabolism and immune regulation in defined experimental settings.

Custom Cd38 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Efficacy and safety of anti-CD38 monoclonal antibodies-based therapy versus standard therapy in newly diagnosed multiple myeloma: a systematic review and meta-analysis. Ther Adv Hematol. 2025. doi:10.1177/20406207251314289
• Jackson DG, Bell JI. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. J Immunol. 1990. doi:10.4049/jimmunol.144.7.2811

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Sdc1 · Cd19 · Slamf7 · Tnfrsf17