CD7 Mouse Models

Why Model CD7

Cd7 is the mouse ortholog of human CD7 and encodes CD7, an immunoglobulin-superfamily glycoprotein expressed on T cells and natural killer cells. CD7 has been associated with roles in T-cell activation.

CD7 is expressed on T-cell acute lymphoblastic leukemia and other T-cell malignancies, and CD7-directed CAR T cells are under study. Cd7-deficient mice are viable with largely preserved lymphocyte development.

Model Applications

Humanized CD7 models, in which the human protein replaces the mouse counterpart, have been used to evaluate CD7-directed therapeutics in defined experimental settings.

Custom CD7 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Sequential CD7 CAR T-cell therapy and allogeneic HSCT without GVHD prophylaxis. N Engl J Med. 2024. doi:10.1056/nejmoa2313812
• Aruffo A, Seed B. Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system. EMBO J. 1987. doi:10.1002/j.1460-2075.1987.tb02651.x

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Cd2 · Cd3e · Klrb1c · Itk